Bowen D M, White P, Spillane J A, Goodhardt M J, Curzon G, Iwangoff P, Meier-Ruge W, Davison A N
Lancet. 1979 Jan 6;1(8106):11-4. doi: 10.1016/s0140-6736(79)90454-9.
Extensive biochemical analysis of whole temporal lobe from cases of dementia and controls suggests that Alzheimer's disease is a primary degenerative nerve-cell disorder and not the result of accelerated ageing. There is selective loss of neocortical cholinergic neurones. Transmitter systems apart from the cholinergic system appears to be affected, but to a lesser extent, and there are no significant changes in the caudate nucleus. The change in cholinergic neurones has been confirmed in biopsy samples.
对痴呆症病例和对照组的整个颞叶进行的广泛生化分析表明，阿尔茨海默病是一种原发性退行性神经细胞疾病，而非加速衰老的结果。新皮质胆碱能神经元存在选择性丧失。除胆碱能系统外的其他递质系统似乎也受到影响，但程度较轻，并且尾状核没有明显变化。胆碱能神经元的变化已在活检样本中得到证实。
