LeGrand E K, Burke J F, Costa D E, Kiorpes T C
Pharmaceutical Research and Development, Ethicon, Inc., Somerville, NJ 08876-0151.
Growth Factors. 1993;8(4):307-14. doi: 10.3109/08977199308991575.
A guinea pig partial thickness skin excision model was used to evaluate the effects of recombinant human PDGF-BB, PDGF-AA, EGF, and bFGF on granulation tissue (neodermis) formation. These growth factors tended to increase the thickness of the granulation tissue bed when assessed histologically at day 7. Using only four animals per group, PDGF-BB at 30 and 100 micrograms/ml consistently and significantly increased the thickness of the granulation bed 2-3 times that of control. Except for the increased thickness, the granulation tissue appeared normal. PDGF-AA and EGF also significantly increased the granulation tissue thickness, and bFGF gave indications of an effect. There was no evidence of synergistic effects between PDGF-BB, EGF, and/or bFGF.
采用豚鼠部分厚度皮肤切除模型来评估重组人血小板衍生生长因子-BB（PDGF-BB）、血小板衍生生长因子-AA（PDGF-AA）、表皮生长因子（EGF）和碱性成纤维细胞生长因子（bFGF）对肉芽组织（新真皮）形成的影响。在第7天进行组织学评估时，这些生长因子往往会增加肉芽组织床的厚度。每组仅使用4只动物，30微克/毫升和100微克/毫升的PDGF-BB持续且显著地使肉芽床厚度增加至对照的2至3倍。除了厚度增加外，肉芽组织看起来正常。PDGF-AA和EGF也显著增加了肉芽组织厚度，bFGF显示出有作用迹象。没有证据表明PDGF-BB、EGF和/或bFGF之间存在协同作用。
