Moroz L L, Park J H, Winlow W
Department of Physiology, University of Leeds, UK.
Neuroreport. 1993 Jun;4(6):643-6. doi: 10.1097/00001756-199306000-00010.
The mollusc, Lymnaea stagnalis, has been used as a model to study the mechanisms of nitric oxide (NO)-dependent processes in the CNS. Putative NO-containing neurones in Lymnaea are localized in the buccal ganglia, predominantly in areas where sensory neurones known to regulate feeding are found. The NO-generating substance, S-nitrosocysteine (S-NC, 5 x 10(-5)-10(-3 M) activates feeding movements of the buccal mass and modulates the activity of buccal motoneurones. An inhibitor of NO synthase, NG-methyl-L-arginine (10(-4) M) decreases the frequency of background buccal movements and has opposite effects to S-NC on the buccal motoneurones. We suggest that NO is a messenger in the CNS of Lymnaea and may be involved in coordination of feeding motor patterns.
椎实螺（Lymnaea stagnalis）已被用作研究中枢神经系统中一氧化氮（NO）依赖性过程机制的模型。椎实螺中假定含NO的神经元位于口神经节，主要分布在已知调节摄食的感觉神经元所在区域。产生NO的物质S-亚硝基半胱氨酸（S-NC，5×10⁻⁵ - 10⁻³ M）可激活口块的摄食运动并调节口运动神经元的活动。NO合酶抑制剂NG-甲基-L-精氨酸（10⁻⁴ M）可降低口部背景运动的频率，并且对口运动神经元的作用与S-NC相反。我们认为NO是椎实螺中枢神经系统中的一种信使，可能参与摄食运动模式的协调。
