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从撒旦牛肝菌(Boletus satanas Lenz)中分离出的一种凝集素——博来毒素的促有丝分裂活性和免疫学特性

Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz.

作者信息

Licastro F, Morini M C, Kretz O, Dirheimer G, Creppy E E, Stirpe F

机构信息

Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.

出版信息

Int J Biochem. 1993 May;25(5):789-92. doi: 10.1016/0020-711x(93)90366-m.

DOI:10.1016/0020-711x(93)90366-m
PMID:8349019
Abstract
  1. A lectin has been purified from the mushroom Boletus satanas Lenz. 2. The protein, called bolesatine, is mitogenic for human T lymphocytes in a dose- and time-dependent manner. 3. Optimal mitogenic doses induce the release of interleukin-1 alpha and interleukin-2 from mononuclear cell cultures.
摘要
  1. 从撒旦牛肝菌(Boletus satanas Lenz)中纯化出一种凝集素。2. 这种名为博来毒素的蛋白质对人T淋巴细胞具有剂量和时间依赖性的促有丝分裂作用。3. 最佳促有丝分裂剂量可诱导单核细胞培养物释放白细胞介素-1α和白细胞介素-2。

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1
Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz.从撒旦牛肝菌(Boletus satanas Lenz)中分离出的一种凝集素——博来毒素的促有丝分裂活性和免疫学特性
Int J Biochem. 1993 May;25(5):789-92. doi: 10.1016/0020-711x(93)90366-m.
2
Effect of bolesatine on phospholipid/calcium dependent protein kinase in Vero cells and in rat thymus.博来霉素对非洲绿猴肾细胞和大鼠胸腺中磷脂/钙依赖性蛋白激酶的作用。
Arch Toxicol. 1995;69(9):624-30. doi: 10.1007/s002040050223.
3
Effect of bolesatine, a glycoprotein from Boletus satanas, on rat thymus in vivo.撒旦牛肝菌中的一种糖蛋白——博来毒素对大鼠胸腺的体内作用。
Toxicology. 1994 Apr 18;89(2):113-8. doi: 10.1016/0300-483x(94)90219-4.
4
Properties of bolesatine, a translational inhibitor from Boletus satanas Lenz. Amino-terminal sequence determination and inhibition of rat mitochondrial protein synthesis.毒红菇(Boletus satanas Lenz)来源的翻译抑制剂博来毒素的特性。氨基末端序列测定及对大鼠线粒体蛋白质合成的抑制作用。
Toxicol Lett. 1992 Dec;64-65 Spec No:763-6. doi: 10.1016/0378-4274(92)90259-m.
5
Purification and some properties of bolesatine, a protein inhibiting in vitro protein synthesis, from the mushroom Boletus satanas Lenz (Boletaceae).从撒旦牛肝菌(牛肝菌科)中提纯一种体外抑制蛋白质合成的蛋白质——牛肝菌毒素,并研究其某些特性。
Arch Toxicol Suppl. 1989;13:422-7. doi: 10.1007/978-3-642-74117-3_83.
6
Characterization of bolesatine, a toxic protein from the mushroom Boletus satanas Lenz and it's effects on kidney cells.撒旦牛肝菌(Boletus satanas Lenz)中一种有毒蛋白质——博来他汀的特性及其对肾细胞的影响
Toxicology. 1991 Feb;66(2):213-24. doi: 10.1016/0300-483x(91)90220-u.
7
Lipid peroxidation induced by bolesatine, a toxin of Boletus satanas: implication in m5dC variation in Vero cells related to inhibition of cell growth.撒旦牛肝菌毒素博来毒素诱导的脂质过氧化:与Vero细胞中5-甲基胞嘧啶变化及细胞生长抑制的关系
Cell Biol Toxicol. 1995 Dec;11(6):347-54. doi: 10.1007/BF01305906.
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Lectin extracts of champedak seeds demonstrate selective stimulation of T lymphocyte proliferation.波罗蜜种子的凝集素提取物表现出对T淋巴细胞增殖的选择性刺激作用。
Biochem Int. 1992 Jun;27(1):139-43.
9
Bolesatine induces agglutination of rat platelets and human erythrocytes and platelets in vitro.波利索他汀在体外可诱导大鼠血小板以及人红细胞和血小板发生凝集。
Hum Exp Toxicol. 1996 Jan;15(1):26-9. doi: 10.1177/096032719601500105.
10
Activation of human T and B lymphocytes by polyclonal mitogens.多克隆有丝分裂原对人T淋巴细胞和B淋巴细胞的激活作用。
Nature. 1974 Apr 19;248(5450):698-701. doi: 10.1038/248698a0.

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