van der Kogel A J
Radiology. 1977 Feb;122(2):505-9. doi: 10.1148/122.2.505.
The cervical or lumbosacral region of the rat spinal cord was irradiated with 300-kV x rays. Syndromes of radiation myelopathy similar to those in man were observed in rats. Iso-effect curves for tolerance in relation to the number of fractions at daily intervals have a slope of 0.44 and 0.42 on a log-log scale for the cervical and lumbosacral regions, respectively. With intervals of up to 7 days, no significant further increase in tolerance was observed. Low dose rate treatments indicate a half-time of 1.5 hr. for repair of subeffective damage. These results suggest that tolerance of the spinal cord depends very strongly on the number of fractions given and only to a small extent on the overall time of treatment.
用300千伏的X射线照射大鼠脊髓的颈部或腰骶部区域。在大鼠中观察到了与人类相似的放射性脊髓病综合征。在对数-对数尺度上，颈部和腰骶部区域每日分次照射的耐受等效应曲线斜率分别为0.44和0.42。间隔时间长达7天时，未观察到耐受性有显著进一步增加。低剂量率治疗表明亚致死性损伤修复的半衰期为1.5小时。这些结果表明，脊髓的耐受性在很大程度上取决于分次照射的次数，而仅在较小程度上取决于治疗的总时间。
