Miller D, Jackson R, Ehlen T, McMurtrie E
Department of Gynecology, University of British Columbia, Vancouver, Canada.
Gynecol Oncol. 1993 Jul;50(1):119-23. doi: 10.1006/gyno.1993.1175.
Twin gestations can occur in which one twin is a normal gestation (46 chromosomes: 23 maternal and 23 paternal origin) and in which the other twin is a complete hydatidiform mole (46 chromosomes all of paternal origin). Case reports of four such combined pregnancies that presented to a single institution are provided. All cases had documentation of clinical information, cytogenetic analysis, and fetal and placental pathology. Three of the four pregnancies were terminated for medical indications despite information documenting the presence of a normal fetus. All three of these patients required subsequent chemotherapy. The fourth case was followed conservatively and resulted in the birth of a normal infant at 38 weeks gestation. We speculate that the factors that led to the need for termination of the pregnancy (aggressive growth of trophoblast) may predict the need for further therapy. A true assessment of the antenatal and malignant sequelae risks associated with these rare gestations awaits the collection of a larger series of patients.
其中一个胎儿为正常妊娠（46条染色体，23条来自母体，23条来自父体），而另一个胎儿为完全性葡萄胎（46条染色体均来自父体）。本文提供了向同一机构就诊的4例此类合并妊娠的病例报告。所有病例均有临床信息、细胞遗传学分析以及胎儿和胎盘病理学的记录。尽管有资料证明存在正常胎儿，但4例妊娠中有3例因医学指征而终止妊娠。这3例患者均需要后续化疗。第4例进行了保守观察，妊娠38周时娩出一名正常婴儿。我们推测，导致终止妊娠的因素（滋养层细胞的侵袭性生长）可能预示着需要进一步治疗。对于这些罕见妊娠相关的产前及恶性后遗症风险的真实评估，有待收集更多病例。
