Barry A L, Pfaller M A, Fuchs P C
Clinical Microbiology Institute, Tualatin, Oregon 97062.
J Clin Microbiol. 1993 Jul;31(7):1932-5. doi: 10.1128/jcm.31.7.1932-1935.1993.
Ramoplanin and mupirocin are two antimicrobial agents that may be applied topically. They had similar potencies against susceptible gram-positive cocci, but they differed in their spectra of activity. In plastic microdilution trays, the in vitro activity of ramoplanin was slightly diminished but that activity was restored by the addition of bovine serum albumin (0.02%). Susceptible strains were defined as those for which MICs of ramoplanin were < or = 2.0 micrograms/ml (without bovine serum albumin) and which had > or = 11-mm zones around 60-micrograms ramoplanin disks. Criteria for a resistant category cannot be defined at this time.
雷莫拉宁和莫匹罗星是两种可局部应用的抗菌剂。它们对敏感革兰氏阳性球菌的效力相似，但活性谱有所不同。在塑料微量稀释板中，雷莫拉宁的体外活性略有降低，但通过添加牛血清白蛋白（0.02%）可恢复该活性。敏感菌株定义为雷莫拉宁的最低抑菌浓度（MIC）<或 = 2.0微克/毫升（无牛血清白蛋白）且在含60微克雷莫拉宁纸片周围有>或 = 11毫米抑菌圈的菌株。目前尚无法定义耐药类别的标准。
