Stricker R B, Kwiatkowska B J, Habis J A, Kiprov D D
Department of Medicine, California Pacific Medical Center, San Francisco, 94120.
Arch Neurol. 1993 Aug;50(8):837-40. doi: 10.1001/archneur.1993.00540080046012.
Myasthenic crisis is a potentially life-threatening complication of myasthenia gravis that requires aggressive therapy. We describe four patients in whom myasthenic crisis developed and who failed to respond to initial treatment with intravenous gamma-globulin. All four patients subsequently responded to intensive plasma exchange. Based on our experience, plasmapheresis appears to be superior to intravenous gamma-globulin for the treatment of myasthenic crisis in certain patients. Prognostic factors that determine the effectiveness of intravenous gamma-globulin vs plasmapheresis in these patients merit further investigation.
重症肌无力危象是重症肌无力一种潜在的危及生命的并发症，需要积极治疗。我们描述了4例发生重症肌无力危象且对静脉注射丙种球蛋白初始治疗无反应的患者。所有4例患者随后对强化血浆置换治疗有反应。根据我们的经验，在某些患者中，血浆置换似乎优于静脉注射丙种球蛋白治疗重症肌无力危象。确定静脉注射丙种球蛋白与血浆置换在这些患者中的有效性的预后因素值得进一步研究。
