Struhl K
Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115.
Curr Opin Cell Biol. 1993 Jun;5(3):513-20. doi: 10.1016/0955-0674(93)90018-l.
Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing number of examples where detailed information is available.