Servo C
Acta Med Scand. 1977 Jan;201(1-2):59-62. doi: 10.1111/j.0954-6820.1977.tb15655.x.
The concentration of myoinositol in plasma, cerebrospinal fluid and red cells and its elimination by the kidneys have been studied in 51 diabetic patients with normal or impaired kidney function, 16 non-diabetic patients with renal failure and 37 healthy controls. All diabetic patients who had a glomerular filtration rate considerably below normal, was the plasma concentration of myoinositol higher than in controls. The findings show that the rise in plasma concentration of myoinositol most probably results from a decreased glomerular filtration rate. In diabetic patients, urinary excretion of myoinositol correlated with an exponential increase in glucose excretion. That myoinositol accumulates in red cells of diabetic patients may be the result of its retention within these cells caused primarily by a transient, abnormal increase in the plasma concentration of myoinositol after an average meal.
对51例肾功能正常或受损的糖尿病患者、16例患有肾衰竭的非糖尿病患者以及37名健康对照者，研究了血浆、脑脊液和红细胞中肌醇的浓度及其经肾脏的清除情况。所有肾小球滤过率显著低于正常水平的糖尿病患者，其血浆肌醇浓度均高于对照组。研究结果表明，血浆肌醇浓度升高很可能是肾小球滤过率降低所致。在糖尿病患者中，肌醇的尿排泄量与葡萄糖排泄量呈指数增加相关。糖尿病患者红细胞中肌醇的蓄积，可能是由于餐后血浆肌醇浓度一过性异常升高，导致肌醇在这些细胞内潴留所致。
