Linnoila M, Stapleton J M, George D T, Lane E, Eckardt M J
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892.
J Clin Psychopharmacol. 1993 Jun;13(3):175-80.
The effects of fluvoxamine (50 or 100 mg), alone and in combination with ethanol (0.8 g/kg), on psychomotor and cognitive performance and on autonomic nervous system reactivity were studied in healthy male volunteers. Fluvoxamine produced neither serious psychomotor or cognitive impairment nor alterations in autonomic nervous system functioning at these doses. There was no evidence that fluvoxamine exacerbated, or improved, ethanol-induced impairments of memory or any other measures evaluated. Fluvoxamine tended to improve recognition, but not free recall, of words.
在健康男性志愿者中研究了氟伏沙明（50或100毫克）单独使用以及与乙醇（0.8克/千克）联合使用对精神运动和认知表现以及自主神经系统反应性的影响。在这些剂量下，氟伏沙明既未产生严重的精神运动或认知损害，也未改变自主神经系统功能。没有证据表明氟伏沙明会加重或改善乙醇引起的记忆损害或所评估的任何其他指标。氟伏沙明倾向于改善对单词的识别，但不能改善自由回忆。
