Jimena I, Peña J, Luque E, Vaamonde R
Department of Morphological Sciences (Section of Histology), Faculty of Medicine, University of Córdoba, Spain.
J Neuropathol Exp Neurol. 1993 Jul;52(4):379-86. doi: 10.1097/00005072-199307000-00005.
The effects of systemic administration of muscle extract on normal muscle were studied. Male Wistar rats received intraperitoneal injections of normal and denervated muscle extract over 5 consecutive days. Soleus muscles were then submitted to histological, histochemical and quantitative-morphometric analysis. The group receiving denervated muscle extract showed considerable muscle fiber hypertrophy, together with the formation of new fibers suggestive of hyperplasia. The systemic administration of denervated muscle extract was shown to have a considerable myotrophic effect on normal muscle, evident in the hypertrophy and hyperplasia of muscle fibers.
研究了全身给予肌肉提取物对正常肌肉的影响。雄性Wistar大鼠连续5天腹腔注射正常和去神经肌肉提取物。然后对比目鱼肌进行组织学、组织化学和定量形态学分析。接受去神经肌肉提取物的组显示出明显的肌纤维肥大，以及提示增生的新纤维形成。结果表明，全身给予去神经肌肉提取物对正常肌肉具有显著的促肌营养作用，表现为肌纤维肥大和增生。
