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洗必泰溶液冲洗可降低使用Cavi-Med超声洁牙时菌血症的发生率:一项初步研究。

Prosol-chlorhexidine irrigation reduces the incidence of bacteremia during ultrasonic scaling with the Cavi-Med: a pilot investigation.

作者信息

Allison C, Simor A E, Mock D, Tenenbaum H C

机构信息

Faculty of Dentistry, University of Toronto.

出版信息

J Can Dent Assoc. 1993 Aug;59(8):673, 676-82.

PMID:8358664
Abstract

The purpose of this pilot investigation was to determine whether the incidence of bacteremia following subgingival ultrasonic scaling and root planing could be reduced by the use, pre- and intraoperatively, of an irrigant containing 0.12 per cent chlorhexidine (CHX); Prosol. Individuals having evidence of significant periodontal disease (minimum of seven sites per quadrant 4.0 mm and bleeding on probing) were entered into this study. By use of a random number table, patients were assigned to either the experimental or control groups. The procedures, as described below, were carried out in a double blind fashion so that neither the investigator nor the patient was aware of whether Prosol or placebo was being used. The placebo solution was flavored to make it indistinguishable from Prosol. Patients were first anesthetized. Their gingival crevices were then irrigated using the Cavi-Med ultrasonic scaler. At this point, the ultrasonic action was not activated. Ten minutes later, ultrasonic scaling and root planing with the Cavi-Med unit were begun with a continuous flow of either the placebo or control solutions. Blood samples were taken preoperatively, while postoperative samples were taken one minute after completing the scaling of each quadrant and then 10 minutes after scaling the second quadrant. Routine aerobic and anaerobic bacterial culture methods were used to identify viable blood-borne bacteria. The results show that there was no difference in the distribution or presentation of periodontal disease between the experimental and control quadrants.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

这项初步调查的目的是确定在龈下超声洁治和根面平整术前及术中使用含0.12%氯己定(CHX)的冲洗剂(Prosol)是否能降低菌血症的发生率。有明显牙周病证据(每个象限至少七个位点,探诊深度4.0毫米且探诊出血)的个体被纳入本研究。通过使用随机数表,将患者分配到实验组或对照组。如下所述,程序以双盲方式进行,这样研究者和患者都不知道使用的是Prosol还是安慰剂。安慰剂溶液添加了调味剂,使其与Prosol难以区分。患者首先接受麻醉。然后使用Cavi - Med超声洁牙器冲洗他们的牙龈沟。此时,超声功能未启动。十分钟后,使用Cavi - Med设备进行超声洁治和根面平整,同时持续冲洗安慰剂或对照溶液。术前采集血样,术后在完成每个象限洁治后一分钟以及完成第二象限洁治后十分钟采集血样。使用常规需氧和厌氧细菌培养方法鉴定存活的血源细菌。结果表明,实验组和对照组象限之间牙周病的分布或表现没有差异。(摘要截断于250字)

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Prosol-chlorhexidine irrigation reduces the incidence of bacteremia during ultrasonic scaling with the Cavi-Med: a pilot investigation.洗必泰溶液冲洗可降低使用Cavi-Med超声洁牙时菌血症的发生率:一项初步研究。
J Can Dent Assoc. 1993 Aug;59(8):673, 676-82.
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引用本文的文献

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Dissemination of periodontal pathogens in the bloodstream after periodontal procedures: a systematic review.牙周治疗后牙周病原体在血液中的播散:一项系统评价
PLoS One. 2014 May 28;9(5):e98271. doi: 10.1371/journal.pone.0098271. eCollection 2014.
2
Microbiology of odontogenic bacteremia: beyond endocarditis.牙源性菌血症的微生物学:超越心内膜炎
Clin Microbiol Rev. 2009 Jan;22(1):46-64, Table of Contents. doi: 10.1128/CMR.00028-08.