Edgar J D, Rooney D P, McNamee P, McNeill T A
Regional Immunology Laboratory, Belfast City Hospital.
Clin Nephrol. 1993 Jul;40(1):22-5.
The detection of anti-neutrophil cytoplasmic antibodies (ANCA) is now a routine part of the evaluation of patients clinically suspected of suffering from small vessel vasculitis. The factor(s) that trigger the development of these autoantibodies and their role in the pathogenesis of vasculitis is still unclear. We describe four patients who presented to us since June 1990. All patients had positive ANCA serology and had clinical evidence of vasculitis. In all patients soon after the establishment of ANCA positivity, a carcinoma of either the respiratory or urinary tracts was diagnosed. We suggest that in some cases of ANCA-associated vasculitis, malignant disease may be a trigger for either the generation of these autoantibodies, or the development of vasculitis.
抗中性粒细胞胞浆抗体（ANCA）检测现已成为临床怀疑患有小血管炎患者评估的常规组成部分。引发这些自身抗体产生的因素及其在血管炎发病机制中的作用仍不清楚。我们描述了自1990年6月以来前来就诊的4例患者。所有患者ANCA血清学检测均为阳性，并有血管炎的临床证据。在所有患者ANCA转为阳性后不久，均被诊断出患有呼吸道或泌尿系统癌症。我们认为，在某些ANCA相关性血管炎病例中，恶性疾病可能是这些自身抗体产生或血管炎发生的触发因素。
