Lafforgue P, Toussirot E, Billé F, Acquaviva P C
Service de Rhumatologie, Hôpital Timone, Marseille, France.
Clin Rheumatol. 1993 Jun;12(2):261-4. doi: 10.1007/BF02231539.
A 63-year-old woman presented with mild arthralgias and inability to stand and walk without other significant neuropsychiatric abnormality. Neurological explorations showed intrathecal oligoclonal immunoglobulin production in CSF and numerous bright foci at brain MRI. A primary Sjögren's syndrome was concomitantly evidenced and was thought to be the cause of the astasia-abasia symptom by multiple brain involvement. Patient's condition gradually improved with hydroxychloroquine and corticosteroid therapy. Central nervous system involvement by primary Sjögren's syndrome is discussed.
一名63岁女性出现轻度关节痛,无法站立和行走,无其他明显神经精神异常。神经检查显示脑脊液中存在鞘内寡克隆免疫球蛋白产生,脑部磁共振成像(MRI)有多个明亮病灶。同时证实患有原发性干燥综合征,认为多灶性脑受累是导致站立不能-步行不能症状的原因。患者病情经羟氯喹和皮质类固醇治疗后逐渐改善。本文讨论了原发性干燥综合征累及中枢神经系统的情况。