炎症性肠病患者体内循环中的人白细胞弹性蛋白酶
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
作者信息
Adeyemi E O, Neumann S, Chadwick V S, Hodgson H J, Pepys M B
出版信息
Gut. 1985 Dec;26(12):1306-11. doi: 10.1136/gut.26.12.1306.
The plasma concentration of human leucocyte elastase (HLE), measured by enzyme immunoassay as the complex with alpha 1-proteinase inhibitor, was determined in 94 patients with active and inactive inflammatory bowel disease. In Crohn's disease and in ulcerative colitis human leucocyte elastase levels were raised significantly above normal when the disease was active, and fell on remission. The mean human leucocyte elastase level in 31 cases of active Crohn's disease was significantly greater than the mean human leucocyte elastase level in 23 patients with active ulcerative colitis (p = 0.013). The values of human leucocyte elastase correlated significantly with Crohn's disease activity index scores (p = 0.05) and with the circulating concentration of C-reactive protein (p less than 0.05 and p less than 0.01 for ulcerative colitis and Crohn's disease respectively), but not with the erythrocyte sedimentation rate. These results indicate that the concentration of human leucocyte elastase in the plasma of patients with inflammatory bowel disease reflects the activity of their intestinal disease and suggest that serial measurements of human leucocyte elastase may be useful in the assessment and clinical management of these conditions.
采用酶免疫分析法测定了94例活动期和非活动期炎症性肠病患者血浆中与α1-蛋白酶抑制剂结合的人白细胞弹性蛋白酶（HLE）浓度。在克罗恩病和溃疡性结肠炎中，疾病活动期时人白细胞弹性蛋白酶水平显著高于正常，缓解期则下降。31例活动期克罗恩病患者的人白细胞弹性蛋白酶平均水平显著高于23例活动期溃疡性结肠炎患者（p = 0.013）。人白细胞弹性蛋白酶的值与克罗恩病活动指数评分显著相关（p = 0.05），与C反应蛋白的循环浓度显著相关（溃疡性结肠炎和克罗恩病分别为p < 0.05和p < 0.01），但与红细胞沉降率无关。这些结果表明，炎症性肠病患者血浆中人白细胞弹性蛋白酶的浓度反映了其肠道疾病的活动情况，并提示连续测定人白细胞弹性蛋白酶可能有助于这些疾病的评估和临床管理。
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