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本文引用的文献

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Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group.多剂量静脉注射白细胞介素10治疗激素难治性克罗恩病。克罗恩病研究小组。
Gastroenterology. 1997 Aug;113(2):383-9. doi: 10.1053/gast.1997.v113.pm9247454.
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The NF-kappa B and I kappa B proteins: new discoveries and insights.核因子κB与IκB蛋白：新发现与见解
Annu Rev Immunol. 1996;14:649-83. doi: 10.1146/annurev.immunol.14.1.649.
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Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein.
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The role of interleukin-1 in disease.白细胞介素-1在疾病中的作用。
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Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea.炎症性肠病或感染性腹泻患儿粪便中的细胞因子。
J Clin Pathol. 1993 Aug;46(8):757-60. doi: 10.1136/jcp.46.8.757.
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Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis.在溃疡性结肠炎中，中性粒细胞的黏膜浸润伴随着白细胞介素-8在局部的产生增加。
Gut. 1993 Sep;34(9):1203-6. doi: 10.1136/gut.34.9.1203.
7
Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.溃疡性结肠炎和克罗恩病患者分离出的固有层单个核细胞中肿瘤坏死因子-α、白细胞介素-6和白细胞介素-1β的分泌增强。
Clin Exp Immunol. 1993 Oct;94(1):174-81. doi: 10.1111/j.1365-2249.1993.tb05997.x.
8
Crohn's disease monocytes are primed for accentuated release of toxic oxygen metabolites.克罗恩病单核细胞易于过度释放毒性氧代谢产物。
Gastroenterology. 1993 Jul;105(1):60-6. doi: 10.1016/0016-5085(93)90010-a.
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PMN-elastase in assessment of patients with inflammatory bowel disease.中性粒细胞弹性蛋白酶在炎症性肠病患者评估中的应用
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10
Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.白细胞介素10（IL-10）可抑制人多形核白细胞释放促炎细胞因子。肿瘤坏死因子和IL-1β在介导脂多糖触发的IL-8产生中自分泌作用的证据。
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肠道炎症期间循环多形核中性粒细胞促炎细胞因子分泌增加及白细胞介素10的调节作用

Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation.

作者信息

Nikolaus S, Bauditz J, Gionchetti P, Witt C, Lochs H, Schreiber S

机构信息

Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany.

出版信息

Gut. 1998 Apr;42(4):470-6. doi: 10.1136/gut.42.4.470.

DOI:10.1136/gut.42.4.470
PMID:9616306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1727082/
Abstract

BACKGROUND

Concentrations of pro-inflammatory cytokines are increased in the intestinal mucosa of patients with active inflammatory bowel disease (IBD). Polymorphonuclear neutrophil granulocytes (PMN) are the most abundant cell type in intestinal lesions in IBD. Interleukin 10 (IL-10) is an important contra-inflammatory cytokine which induces downregulation of pro-inflammatory cytokines.

AIMS

To investigate whether PMN from patients with IBD or infectious colitis, respectively, secrete increased amounts of pro-inflammatory cytokines and can be regulated by IL-10.

METHODS

Secretion (ELISA) as well as corresponding mRNA levels (semiquantitative RT-PCR) of pro-inflammatory cytokines (IL-1 beta, TNF-alpha) and of IL-1 receptor antagonist were assessed in peripheral PMN.

RESULTS

PMN from patients with IBD are primed to secrete enhanced amounts of pro-inflammatory cytokines accompanied by detection of corresponding mRNAs in comparison with normal controls. This finding is not specific for IBD but rather reflects intestinal inflammation in general. IL-10 markedly inhibited proinflammatory cytokine secretion as well as corresponding mRNA concentrations.

CONCLUSIONS

PMN are an important source of pro-inflammatory cytokines in patients with intestinal inflammation and can be downregulated by IL-10.

摘要

背景

在活动性炎症性肠病（IBD）患者的肠道黏膜中，促炎细胞因子的浓度会升高。多形核中性粒细胞（PMN）是IBD肠道病变中最丰富的细胞类型。白细胞介素10（IL-10）是一种重要的抗炎细胞因子，可诱导促炎细胞因子的下调。

目的

分别研究IBD患者或感染性结肠炎患者的PMN是否分泌更多的促炎细胞因子，以及是否可被IL-10调节。

方法

通过酶联免疫吸附测定法（ELISA）以及半定量逆转录聚合酶链反应（RT-PCR）评估外周血PMN中促炎细胞因子（IL-1β、TNF-α）和IL-1受体拮抗剂的分泌情况及其相应的mRNA水平。

结果

与正常对照相比，IBD患者的PMN易于分泌更多的促炎细胞因子，同时可检测到相应的mRNA。这一发现并非IBD所特有，而是反映了一般性的肠道炎症。IL-10可显著抑制促炎细胞因子的分泌以及相应的mRNA浓度。

结论

PMN是肠道炎症患者促炎细胞因子的重要来源，且可被IL-10下调。