乳糜泻与特定 HLA-DQ α/β 异二聚体存在主要关联的证据。
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
作者信息
Sollid L M, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E
机构信息
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
出版信息
J Exp Med. 1989 Jan 1;169(1):345-50. doi: 10.1084/jem.169.1.345.
Abstract
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.
摘要
采用HLA - DQA1和 - DQB1等位基因特异性寡核苷酸探针，对94名无亲缘关系的乳糜泻（CD）患儿进行DNA分型，结果显示，除1名患儿外（即98.9%），所有患儿可能共享一种特定的DQA1和DQB1基因组合。这些基因在DR3DQw2单倍型上呈顺式排列，在DR5DQw7/DR7DQw2杂合个体中呈反式排列。因此，大多数CD患者可能共享相同的顺式或反式编码的HLA - DQα/β异二聚体。
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本文引用的文献
1
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Gut. 1983 Jun;24(6):532-7. doi: 10.1136/gut.24.6.532.
2
Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.HLA-DC Ⅱ类组织相容性抗原的α链和β链在其氨基末端结构域均表现出广泛的多态性。
EMBO J. 1984 Feb;3(2):447-52. doi: 10.1002/j.1460-2075.1984.tb01826.x.
3
Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.人类主要组织相容性复合体基因DC-3β的克隆与序列分析
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5199-203. doi: 10.1073/pnas.81.16.5199.
4
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5
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Gut. 1985 Nov;26(11):1210-3. doi: 10.1136/gut.26.11.1210.
6
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