Ponnachan P T, Paulose C S, Panikkar K R
Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
Indian J Exp Biol. 1993 Apr;31(4):345-7.
Alloxan induced animal model was used to evaluate the potential antidiabetic effect of A. marmelose leaf extract. The diabetic animals were given insulin injection and another group A. marmelose leaf extract orally. It maintained the weight of the animals near to the control rats but a significant decrease in weight was noted in diabetic animals without any treatment. The blood glucose level in treated animals were near to that of control ones. Also a significantly increased glucose tolerance was observed in animals orally given the leaf extract prior to the experiment. A significant decrease in liver glycogen (1.24 +/- .07 g/100 g of wet tissue) was observed in diabetic rats which was brought to almost the normal level (1.84 +/- .14 g/100 g) with leaf extract treatment. Blood urea and serum cholesterol increased (62.66 +/- 3.50 and 192.67 +/- 13.64 mg/dl) significantly in alloxan diabetic rats. The leaf extract treatment decreased the blood urea and serum cholesterol (37.83 +/- 3.97 and 99.20 +/- 8.43 mg/dl) to that of control ones. A similar effect was seen with insulin treatment. The results indicate that the active principle in A. marmelose leaf extract has similar hypoglycaemic activity to insulin treatment.
使用四氧嘧啶诱导的动物模型来评估马梅洛叶提取物的潜在抗糖尿病作用。给糖尿病动物注射胰岛素，另一组口服马梅洛叶提取物。它使动物的体重维持在接近对照大鼠的水平，但未接受任何治疗的糖尿病动物体重显著下降。接受治疗的动物的血糖水平接近对照动物。此外，在实验前口服叶提取物的动物中观察到葡萄糖耐量显著增加。糖尿病大鼠的肝糖原显著减少（1.24±0.07克/100克湿组织），经叶提取物治疗后几乎恢复到正常水平（1.84±0.14克/100克）。四氧嘧啶糖尿病大鼠的血尿素和血清胆固醇显著升高（分别为62.66±3.50和192.67±13.64毫克/分升）。叶提取物治疗使血尿素和血清胆固醇降低至对照水平（分别为37.83±3.97和99.20±8.43毫克/分升）。胰岛素治疗也有类似效果。结果表明，马梅洛叶提取物中的活性成分具有与胰岛素治疗相似的降血糖活性。
