Vijayan E, Jayashree J
School of Life Sciences, Pondicherry University, India.
Indian J Exp Biol. 1993 Apr;31(4):386-8.
Administration of bromocriptine (Bc), an ergot derivative having dopamine receptor agonist activity, to rats on day 1-5 of pregnancy prevented implantation of blastocysts and significantly suppressed uterine glucosamine 6-phosphate synthase activity. There was no effect on implantation or the enzyme activity when Bc was injected on day 7 or later of pregnancy. Injection of prolactin following Bc partially restored the enzyme activity and increased number of implantation sites. These results indicate that suppression of prolactin on day 1 to 5 of pregnancy causes failure of implantation. Bc on day 9 or later had no effect possibly due to the availability of placental LH/hCG to support the luteal cells.
在妊娠第1至5天给大鼠注射溴隐亭（Bc），一种具有多巴胺受体激动剂活性的麦角衍生物，可阻止胚泡着床，并显著抑制子宫葡萄糖胺6 - 磷酸合酶活性。在妊娠第7天或之后注射Bc对着床或酶活性没有影响。在注射Bc后注射催乳素可部分恢复酶活性并增加着床部位的数量。这些结果表明，妊娠第1至5天催乳素的抑制导致着床失败。第9天或之后的Bc没有影响，可能是由于胎盘促黄体生成素/人绒毛膜促性腺激素可支持黄体细胞。
