Rinke de Wit T F, Bekelie S, Osland A, Wieles B, Janson A A, Thole J E
Armauer Hansen Research Institute, Addis Ababa University, Ethiopia.
Infect Immun. 1993 Sep;61(9):3642-7. doi: 10.1128/iai.61.9.3642-3647.1993.
The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients.
分离出了麻风分枝杆菌抗原85复合蛋白家族两个新成员（命名为85A和85C）的基因以及密切相关的麻风分枝杆菌MPT51蛋白的基因。给出了麻风分枝杆菌85C基因的完整DNA序列以及85A和MPT51基因的部分序列。与结核分枝杆菌一样，麻风分枝杆菌的85A、85C以及先前鉴定的85B组成基因在基因组上并非紧密连锁。然而，这两个物种的MPT51基因都定位在各自的85A组成基因附近。与85B组成部分一样，麻风分枝杆菌的85A-MPT51和85C抗原可被健康接触者和麻风病患者的T细胞识别。
