MacGregor R R
Antimicrob Agents Chemother. 1977 Jan;11(1):110-3. doi: 10.1128/AAC.11.1.110.
Using a rabbit sterile peritonitis model, we compared the penetration of intravenously administered amikacin, gentamicin, and penicillin G into peritoneal exudate. Peritonitis was induced with sterile normal saline, and the peritoneal exudate contained 23,751 +/- 3,039 granulocytes 8 h later. Antibiotics were administered intravenously 3 h after initiating peritonitis, and serum and peritoneal fluid concentrations were measured for 5 h. Peritoneal levels of each antibiotic exceeded simultaneous serum levels by 1 h after dose and remained above serum levels thereafter. The maximum peritoneal fluid concentration of amikacin reached 71.2% +/- 12.7 of the maximum serum concentration, whereas maximum gentamicin peritoneal concentration achieved 37.1% +/- 2.7, and penicillin achieved 23.2% +/- 4.5, of their respective maximum serum concentrations.
我们使用兔无菌性腹膜炎模型，比较了静脉注射阿米卡星、庆大霉素和青霉素G在腹膜渗出液中的渗透情况。用无菌生理盐水诱发腹膜炎，8小时后腹膜渗出液中含有23,751±3,039个粒细胞。腹膜炎开始3小时后静脉注射抗生素，并在5小时内测量血清和腹膜液浓度。每种抗生素的腹膜水平在给药后1小时超过同期血清水平，并在此后一直高于血清水平。阿米卡星的最大腹膜液浓度达到其最大血清浓度的71.2%±12.7%，而庆大霉素的最大腹膜浓度为其最大血清浓度的37.1%±2.7%，青霉素为23.2%±4.5%。
