Mayerl F, Gao Q, Huang S, Klohr S E, Matson J A, Gustavson D R, Pirnik D M, Berry R L, Fairchild C, Rose W C
Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492.
J Antibiot (Tokyo). 1993 Jul;46(7):1082-8. doi: 10.7164/antibiotics.46.1082.
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
由短柄拟青霉ATCC 74184的培养物经提取和结晶分离得到了优彭尼非定。基于光谱数据，该化合物被鉴定为五环双托酚酮，其完整结构通过单晶X射线分析得以确定。该化合物对HCT - 116细胞系具有细胞毒性，并且在P388白血病模型中具有体内抗肿瘤活性。
