Lemann J, Pleuss J A, Gray R W
Department of Medicine, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
J Nutr. 1993 Sep;123(9):1623-6. doi: 10.1093/jn/123.9.1623.
The administration of 60 mmol/d of KHCO3 to healthy adults reduced urinary calcium excretion by 0.9 mmol/d and caused calcium balance to become equivalently more positive. Other studies showed that 90 mmol/d of KHCO3 reduced both daily and fasting urinary calcium excretion rates, whereas deprivation of either KCl or KHCO3, using synthetic diets, was accompanied by increased daily and fasting urinary calcium excretion rates. A significant inverse relationship between the changes in urinary calcium and the changes in urinary potassium was observed: delta urinary Ca (mmol/d) = 0.29-0.015 delta urinary K (mmol/d); r = -0.65. Correlative evaluation of additional data suggested that the fall in urinary calcium during potassium administration may be related to the natriuretic effects of potassium, resulting in ECF-volume contraction or to potassium-induced phosphate retention and suppression of calcitriol synthesis, or to both mechanisms.
给健康成年人每日服用60毫摩尔的碳酸氢钾可使尿钙排泄量每日减少0.9毫摩尔，并使钙平衡相应地变得更加正向。其他研究表明，每日服用90毫摩尔的碳酸氢钾可降低每日及空腹尿钙排泄率，而使用合成饮食剥夺氯化钾或碳酸氢钾会伴随着每日及空腹尿钙排泄率的增加。观察到尿钙变化与尿钾变化之间存在显著的负相关关系：尿钙变化量（毫摩尔/天）= 0.29 - 0.015×尿钾变化量（毫摩尔/天）；r = -0.65。对更多数据的相关评估表明，服用钾期间尿钙的下降可能与钾的利钠作用有关，导致细胞外液量收缩，或者与钾诱导的磷酸盐潴留及骨化三醇合成受抑制有关，或与这两种机制都有关。
