Hollenbach K A, Barrett-Connor E, Edelstein S L, Holbrook T
Department of Family and Preventive Medicine, University of California-San Diego, La Jolla 92093-0607.
Am J Public Health. 1993 Sep;83(9):1265-70. doi: 10.2105/ajph.83.9.1265.
The association between cigarette smoking and bone mineral density was examined prospectively in a population-based study of older Caucasian men and women.
Smoking patterns were determined at a 1972-1974 baseline evaluation and, again, 16 years later when 544 men and 822 women had bone mineral density measurements taken.
Men and women who were cigarette smokers at baseline demonstrated significantly reduced bone mineral density of the hip compared with nonsmokers. Baseline smoking was not associated with significantly lower bone density at non-hip sites. Women demonstrated a significant dose-response relationship between baseline smoking status at all hip sites measured. Both sexes exhibited significant dose-response relationships between hip bone mineral density and change in smoking status between baseline and follow-up, demonstrating that smoking cessation in later life was beneficial in halting bone density loss associated with smoking.
Smoking was positively and significantly associated with decreased hip bone mineral density in old age. Bone loss associated with smoking would be expected to predict an increased risk of hip fracture in those who do not succumb earlier to another complication of tobacco use.
在一项针对老年白种男性和女性的基于人群的研究中，对吸烟与骨密度之间的关联进行前瞻性研究。
在1972 - 1974年的基线评估时确定吸烟模式，16年后再次确定，此时对544名男性和822名女性进行了骨密度测量。
与不吸烟者相比，基线时吸烟的男性和女性髋部骨密度显著降低。基线吸烟与非髋部部位骨密度显著降低无关。在所有测量的髋部部位，女性基线吸烟状况之间呈现显著的剂量反应关系。在髋部骨密度与基线和随访之间吸烟状况的变化之间，两性均呈现显著的剂量反应关系，表明晚年戒烟有利于阻止与吸烟相关的骨密度损失。
吸烟与老年髋部骨密度降低呈正相关且具有显著性。预计与吸烟相关的骨质流失会增加那些没有更早死于吸烟其他并发症的人髋部骨折的风险。
