Pi-Sunyer F X
St. Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York.
Ann Intern Med. 1993 Oct 1;119(7 Pt 2):722-6. doi: 10.7326/0003-4819-119-7_part_2-199310011-00019.
Weight loss reduces many of the health hazards associated with obesity including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, sleep apnea, hypoxemia and hypercarbia, and osteoarthritis. Potential adverse effects of weight loss include a greater risk for gallstone formation and cholecystitis, excessive loss of lean body mass, water and electrolyte problems, mild liver dysfunction, and elevated uric acid levels. Less consequential problems such as diarrhea, constipation, hair loss, and cold intolerance may also occur. The short-term adverse effects are not severe enough to contraindicate weight loss, nor do they outweigh its short-term benefits.
体重减轻可减少许多与肥胖相关的健康危害，包括胰岛素抵抗、糖尿病、高血压、血脂异常、睡眠呼吸暂停、低氧血症和高碳酸血症以及骨关节炎。体重减轻的潜在不良反应包括胆结石形成和胆囊炎的风险增加、瘦体重过度流失、水和电解质问题、轻度肝功能障碍以及尿酸水平升高。也可能出现一些不太严重的问题，如腹泻、便秘、脱发和不耐寒。短期不良反应并不严重到足以成为体重减轻的禁忌证，其短期益处也超过这些不良反应。
