School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
NovinDiet Clinic, Tehran, Iran.
Int J Obes (Lond). 2018 Apr;42(4):835-840. doi: 10.1038/ijo.2017.306. Epub 2017 Dec 21.
Beneficial effects of replacing diet beverages (DBs) with water on weight loss, during a 24-week hypoenergetic diet were previously observed. However, it is not known whether this difference is sustained during a subsequent 12-month weight maintenance period.
To evaluate effects of replacing DBs with water on body weight maintenance over a 12-month period in participants who undertook a 6-month weight loss plan.
Seventy-one obese and overweight adult women (body mass index (BMI): 27-40 kg m; age: 18-50 years) who usually consumed DBs in their diet were randomly assigned to either substitute water for DBs (water group: 35) or continue drinking DBs five times per week (DBs group: 36) after their lunch for the 6-month weight loss intervention and subsequent 12-month weight maintenance program.
A total of 71 participants who were randomly assigned were included in the study by using an intention-to-treat analysis. Greater additional weight loss (mean±s.d.) in the water group was observed compared with the DBs group after the 12-month follow-up period (-1.7±2.8 vs -0.1±2.7 kg, P=0.001). BMI decreased more in the water group than in the DBs group (-0.7±1 vs -0.05±1.1 kg m, P=0.003). There was also a greater reduction in fasting insulin levels (-0.5±1.4 vs -0.02±1.5 mmol l, P=0.023), better improvement in homeostasis model assessment of insulin resistance (-0.2±0.4 vs -0.1±0.3, P=0.013) and a greater decrease in 2-h postprandial plasma glucose (-0.2±0.3 vs -0.1±0.3 mmol l, P<0.001) in the water group compared with the DBs over the 12-month weight maintenance period.
Replacement of DBs with water after the main meal in women who were regular users of DBs may cause further weight reduction during a 12-month weight maintenance program. It may also offer benefits in carbohydrate metabolism including improvement of insulin resistance over the long-term weight maintenance period.
在为期 24 周的低能量饮食期间，用饮用水替代饮食饮料（DB）对减肥有有益影响。然而，在随后的 12 个月体重维持期间，这种差异是否持续尚不清楚。
评估在接受 6 个月减肥计划的参与者中，用饮用水替代 DB 对 12 个月期间体重维持的影响。
71 名肥胖和超重成年女性（体重指数（BMI）：27-40kg/m；年龄：18-50 岁），通常在饮食中饮用 DB，在 6 个月的减肥干预和随后的 12 个月体重维持计划中，随机分为两组：用饮用水替代 DB（水组：35 人）或午餐后继续每周饮用 DB 五次（DB 组：36 人）。
共有 71 名随机分配的参与者通过意向治疗分析纳入研究。在 12 个月随访期间，水组的体重额外减轻更多（平均±标准差）（-1.7±2.8 比-0.1±2.7kg，P=0.001）。水组 BMI 下降多于 DB 组（-0.7±1 比-0.05±1.1kg/m，P=0.003）。空腹胰岛素水平也有更大幅度的降低（-0.5±1.4 比-0.02±1.5mmol/l，P=0.023），稳态模型评估的胰岛素抵抗得到更好的改善（-0.2±0.4 比-0.1±0.3，P=0.013），餐后 2 小时血糖也有更大幅度的降低（-0.2±0.3 比-0.1±0.3mmol/l，P<0.001）。
在经常饮用 DB 的女性中，在用餐结束后用饮用水替代 DB，可能会在 12 个月的体重维持期间进一步减轻体重。在长期的体重维持期间，它还可能在碳水化合物代谢方面带来益处，包括改善胰岛素抵抗。
