Becker B A, Gaspari A A
Department of Dermatology, Strong Memorial Hospital, Rochester, New York.
Dermatol Clin. 1993 Jul;11(3):429-52.
Pemphigus vulgaris, which has multiple clinical variants, is an autoimmune blistering disorder of skin and mucous membranes, usually affecting the elderly, with a strong immunogenetic link. Immunologic studies of this disease have been productive in defining the pathophysiology of blister formation and the characteristics of the pemphigus antigen. New therapies resulting from the newest research techniques would prevent the global immunosuppression that occurs during drug therapy with systemic glucocorticoids, which is the cornerstone of therapy for patients afflicted with this potentially life-threatening disorder.
寻常型天疱疮有多种临床变体，是一种皮肤和黏膜的自身免疫性水疱性疾病，通常影响老年人，有很强的免疫遗传学关联。对该疾病的免疫学研究在确定水疱形成的病理生理学和天疱疮抗原的特征方面成果丰硕。最新研究技术带来的新疗法将避免在使用系统性糖皮质激素进行药物治疗期间出现的全身免疫抑制，而系统性糖皮质激素治疗是患有这种潜在危及生命疾病的患者的治疗基石。
