Fedler R, Strömer K
Clinic for Dermatology and Allergy, Alexanderhausklinik, Davos, Switzerland.
Contact Dermatitis. 1993 Aug;29(2):65-9. doi: 10.1111/j.1600-0536.1993.tb03484.x.
A prospective study of 552 persons was performed to study nickel allergy in atopics, with and without dermatitis, psoriatics and healthy adults. We found no statistically-significant difference in the frequency of nickel allergy between persons with atopic dermatitis, atopics without dermatitis and healthy controls. More females than men gave a history of metal intolerance and gave allergic patch test reactions. A poor correlation between history and patch test reaction was not specific for atopics. Psoriatics had a significantly lower frequency of allergic patch test reactions to nickel than healthy controls or atopics with and without dermatitis. Psoriatics should not be used as controls for atopics in studies of contact dermatitis.
对552人进行了一项前瞻性研究，以研究患有或不患有皮炎的特应性个体、银屑病患者和健康成年人中的镍过敏情况。我们发现，患有特应性皮炎的个体、无皮炎的特应性个体和健康对照者之间，镍过敏的发生率在统计学上没有显著差异。报告有金属不耐受史并出现过敏性斑贴试验反应的女性多于男性。病史与斑贴试验反应之间相关性较差并非特应性个体所特有。银屑病患者对镍的过敏性斑贴试验反应发生率显著低于健康对照者或患有或不患有皮炎的特应性个体。在接触性皮炎研究中，银屑病患者不应作为特应性个体的对照。
