Jiang D J, Wilson D F, Wiebkin O W
Department of Dentistry, University of Adelaide, South Australia.
J Comp Pathol. 1993 May;108(4):375-81. doi: 10.1016/s0021-9975(08)80209-5.
An electron microscopical examination of normal rat lingual mucosa and 4-nitroquinoline 1-oxide (4NQO)-induced tongue carcinomas was undertaken. In normal rat tongue, the epithelium of papillae and interpapillary regions exhibited two distinct keratohyalin granule types and essentially similar ultrastructural cellular features in the different epithelial compartments. The interface between epithelium and connective tissue showed a continuous basal lamina. Compared with normal rat tongue epithelium, 4NQO-induced oral carcinomas revealed cellular and nuclear pleomorphism, atypical tonofilament aggregates, increased and swollen mitochondria, dilated intercellular spaces, local discontinuities and thickening of the basal lamina.
对正常大鼠舌黏膜和4-硝基喹啉-1-氧化物（4NQO）诱导的舌癌进行了电子显微镜检查。在正常大鼠舌中，乳头和乳头间区域的上皮表现出两种不同类型的透明角质颗粒，并且在不同的上皮区域具有基本相似的超微结构细胞特征。上皮与结缔组织之间的界面显示出连续的基膜。与正常大鼠舌上皮相比，4NQO诱导的口腔癌表现出细胞和核的多形性、非典型张力丝聚集、线粒体增多和肿胀、细胞间隙增宽、基膜局部中断和增厚。
