Pharmacology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Plant Protection Department, Faculty of Agriculture, Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Sci Rep. 2022 Dec 1;12(1):20765. doi: 10.1038/s41598-022-24727-z.
Hypertension-induced ventricular and vascular remodeling causes myocardial infarction, heart failure, and sudden death. Most available pharmaceutical products used to treat hypertension lead to adverse effects on human health. Limited data is available on apitherapy (bee products) combinations for treatment of hypertension. This study aims to evaluate the antihypertensive effects of combinations of natural apitherapy compounds used in the medical sector to treat a variety of diseases. Rats were assigned into six groups consisting of one control group and five hypertensive groups where hypertension (blood pressure > 140/90) was induced with dexamethasone. One of these groups was used as a hypertension model, while the remaining four hypertensive groups were treated with a propolis, royal jelly, and bee venom combination (PRV) at daily oral doses of 0.5, 1.0, and 2.0 mg/kg, and with losartan 10 mg/kg. The PRV combination at all doses decreased arterial blood pressure below the suboptimal value (p < 0.001), and PRV combination treatment improved dexamethasone-induced-ECG changes. The same treatment decreased angiotensin-II, endothelin-1, and tumor growth factor β serum levels in hypertensive rats. Additionally, PRV combination improved histopathological structure, and decreased serum levels of NF-kB and oxidative stress biomarkers. We concluded that PRV combination therapy may be used as a potential treatment for a variety of cardiovascular diseases.
高血压引起的心室和血管重构导致心肌梗死、心力衰竭和猝死。大多数用于治疗高血压的现有药物都会对人类健康产生不良反应。关于蜂疗（蜜蜂产品）联合治疗高血压的可用数据有限。本研究旨在评估用于治疗各种疾病的天然蜂疗化合物组合的降压作用。将大鼠分为六组，包括一组对照组和五组高血压组，其中用地塞米松诱导高血压（血压>140/90）。其中一组用作高血压模型，而其余四组高血压组分别用蜂胶、蜂王浆和蜂毒混合物（PRV）以每天 0.5、1.0 和 2.0mg/kg 的口服剂量和 10mg/kg 的洛沙坦进行治疗。PRV 组合在所有剂量下均使动脉血压降至低于最佳值（p<0.001），并且 PRV 组合治疗改善了地塞米松诱导的 ECG 变化。相同的治疗降低了高血压大鼠的血管紧张素-II、内皮素-1 和肿瘤生长因子-β 血清水平。此外，PRV 组合改善了组织病理学结构，并降低了 NF-kB 和氧化应激生物标志物的血清水平。我们得出结论，PRV 联合治疗可能可用于治疗各种心血管疾病。
