Walker N I, Smith M M, Smithers B M
Department of Pathology, Royal Brisbane Hospital, Herston, Australia.
Pathology. 1993 Apr;25(2):120-3. doi: 10.3109/00313029309084783.
Colonic mucosal biopsies from patients with melanosis coli were examined by electron microscopy. They showed apoptosis of colonic surface epithelial cells and phagocytosis of resulting apoptotic bodies by intraepithelial macrophages. The latter migrated to the lamina propria where intracellular degradation of the apoptotic bodies resulted in formation of lipofuscin, characteristic of this condition. The results showed the pathogenesis of human melanosis coli was identical to that determined in an animal model of this disease.
对患有结肠黑变病患者的结肠黏膜活检组织进行了电子显微镜检查。结果显示结肠表面上皮细胞发生凋亡，上皮内巨噬细胞对产生的凋亡小体进行吞噬。后者迁移至固有层，在固有层中凋亡小体的细胞内降解导致脂褐素形成，这是该病症的特征。结果表明人类结肠黑变病的发病机制与该疾病动物模型中所确定的发病机制相同。
