YAC transgenes: bigger is probably better.
作者信息
Forget B G
机构信息
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8021.
出版信息
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7909-11. doi: 10.1073/pnas.90.17.7909.
Abstract
摘要
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Curr Biol. 1992 May;2(5):262-4. doi: 10.1016/0960-9822(92)90379-o.
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Transcriptional regulation of multigene loci: multilevel control.多基因位点的转录调控：多级控制。
Trends Genet. 1993 Apr;9(4):134-7. doi: 10.1016/0168-9525(93)90208-y.
3
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.一个覆盖酪氨酸酶基因的酵母人工染色体在转基因小鼠中赋予了拷贝数依赖性表达。
Nature. 1993 Mar 18;362(6417):258-61. doi: 10.1038/362258a0.
4
Germ-line transmission and expression of a human-derived yeast artificial chromosome.人源酵母人工染色体的种系传递与表达
Nature. 1993 Mar 18;362(6417):255-8. doi: 10.1038/362255a0.
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Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.携带人类β-珠蛋白基因座的248千碱基酵母人工染色体的转基因小鼠表现出人类珠蛋白基因的正常发育调控。
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7593-7. doi: 10.1073/pnas.90.16.7593.
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Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome.转基因小鼠，其包含克隆于酵母人工染色体中的人类重链免疫球蛋白基因片段。
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