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[锂与甲状腺功能亢进症]

[Lithium and hyperthyroidism].

作者信息

Brogmus K E, Winiarski B

机构信息

Stiftung Tannenhof, Evangelische Nervenklinik, Remscheid-Lüttringhausen.

出版信息

Psychiatr Prax. 1993 Mar;20(2):74-7.

PMID:8367545
Abstract

The development of hypothyroidism and the forming of a goiter are well-known complications associated with lithium medications. But there are also occasional references to cases of hyperthyroidism in the wake of both continual and of discontinued lithium medication. In the case being reported on here of a lady patient aged 64 and suffering from a toxic adenoma not recognized at the time, thyrotoxicosis accompanied by above-normal FT-3 results and the characteristic clinical symptoms developed when lithium medication was discontinued. Medical literature consulted in the context discussed pharmacological mechanisms which may be responsible for the said complications.

摘要

甲状腺功能减退的发展以及甲状腺肿的形成是与锂药物相关的众所周知的并发症。但也偶尔有关于在持续和停用锂药物后出现甲状腺功能亢进病例的报道。在此报告的一例64岁女性患者,当时患有未被识别的毒性腺瘤,在停用锂药物时出现了伴有FT-3结果高于正常水平的甲状腺毒症及典型临床症状。在所讨论背景下查阅的医学文献探讨了可能导致上述并发症的药理机制。

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