Jeejeebhoy H F
Br J Cancer. 1977 Feb;35(2):161-9. doi: 10.1038/bjc.1977.23.
Lymphocytes from 10 patients with breast carcinoma were seeded in autologous serum, on autochthonous tumour cells and allogeneic tissue-cultured breast tumour cell lines. In 4 patients, the anti-tumour cell cytotoxicity against at least one of 3 breast tumour cell lines differed significantly from that against autochthonous tumour cells. Further study of these 4 individuals (using their previously frozen lymphoid cells and sera) showed that these differences occurred because serum which decreased ("blocked") lymphocyte anti-tumour cytotoxicity when applied to one tumour cell line, could either have no effect or potentiate it when applied to another, without any consistent pattern vis-à-vis target-cell susceptibility to these different humoral effects.
从10例乳腺癌患者采集的淋巴细胞，接种于自体血清中、自身肿瘤细胞上以及同种异体组织培养的乳腺肿瘤细胞系上。在4例患者中，针对3种乳腺肿瘤细胞系中至少一种的抗肿瘤细胞细胞毒性，与针对自身肿瘤细胞的细胞毒性有显著差异。对这4例个体（使用其先前冻存的淋巴细胞和血清）的进一步研究表明，出现这些差异是因为当血清作用于一种肿瘤细胞系时会降低（“阻断”）淋巴细胞抗肿瘤细胞毒性，但作用于另一种肿瘤细胞系时可能没有影响或增强这种毒性，而且相对于靶细胞对这些不同体液效应的易感性而言，不存在任何一致的模式。
