Gonzalez C H, Vargas F R, Perez A B, Kim C A, Brunoni D, Marques-Dias M J, Leone C R, Correa Neto J, Llerena Júnior J C, de Almeida J C
Department of Orthopedics, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Am J Med Genet. 1993 Aug 1;47(1):59-64. doi: 10.1002/ajmg.1320470113.
Misoprostol, a synthetic analog of prostaglandin, has been widely used in Brazil as an abortifacient. Abortion is illegal in Brazil. An uncertain number of these abortion attempts are unsuccessful and the pregnancy continues. We report on 7 patients whose mothers attempted to abort using this drug in the first trimester of gestation without success. The 7 patients presented with limb defects and in 4 of them a diagnosis of Möbius sequence was made.
米索前列醇是一种前列腺素的合成类似物，在巴西已被广泛用作堕胎药。堕胎在巴西是非法的。这些堕胎尝试中有不确定数量未成功，妊娠继续。我们报告了7例患者，他们的母亲在妊娠早期试图使用这种药物堕胎但未成功。这7例患者出现肢体缺陷，其中4例被诊断为莫比乌斯序列。
