Bornstein R A, Fama R, Rosenberger P, Whitacre C C, Para M F, Nasrallah H A, Fass R J
Department of Psychiatry, Ohio State University, Columbus 43210.
J Neuropsychiatry Clin Neurosci. 1993 Summer;5(3):254-9. doi: 10.1176/jnp.5.3.254.
The effect of drug and alcohol abuse on neuropsychological performance was examined in 132 human immunodeficiency virus-seropositive gay or bisexual men. Syndromal (diagnostic) criteria of alcohol/drug abuse based on DSM-III-R were used, and quantitative estimates of alcohol consumption were obtained. Very few differences appeared between substance abuse subgroups formed on the basis of recency or severity of drug use. There were some correlations with the quantitative estimate of alcohol use, but not on the measures previously found to differentiate seronegative and asymptomatic seropositive gay men. These data indicate that alcohol use does affect neuropsychological performance but does not account for the differences observed in studies of seronegative and seropositive subjects.
在132名人类免疫缺陷病毒血清反应呈阳性的男同性恋者或双性恋男性中，研究了药物和酒精滥用对神经心理表现的影响。采用基于《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）的酒精/药物滥用综合征（诊断）标准，并获得了酒精消费量的定量估计。基于近期用药情况或用药严重程度形成的物质滥用亚组之间几乎没有差异。与酒精使用的定量估计存在一些相关性，但与先前用于区分血清反应阴性和无症状血清反应阳性男同性恋者的指标无关。这些数据表明，饮酒确实会影响神经心理表现，但无法解释在血清反应阴性和血清反应阳性受试者研究中观察到的差异。
