Boulton A A, Juorio A V, Philips S R, Wu P H
Br J Pharmacol. 1977 Jan;59(1):209-14. doi: 10.1111/j.1476-5381.1977.tb06996.x.
1 The concentrations of p- and m-tyramine were measured in the caudate nucleus of the rat brain following subcutaneous injection of reserpine or intraventricular injection of 6-hydroxydopamine, beta-Phenylethylamine was analysed in the hypothalamus after reserpine. 2 Endogenous levels of p-tyramine and m-tyramine in the caudate nucleus, and beta-phenylethylamine in the hypothalamus were 8.02, 2.25 and 2.52 ng/g respectively. 3 Tyramine concentrations were reduced to less than 20% of control values one day after a reserpine injection of 1 or 10 mg/kg. A single dose of reserpine (0.4 mg/kg) significantly decreased the content of both tyramines in the caudate nucleus. The effects became apparent as early as 45 min after drug case of m-tyramine. 4 The hypothalamic content of beta-phenylethylamine was unaffected by reserpine. 5 Ten days after an intraventricular injection of 6-hydroxydopamine (250 mug), p- and m-tyramine concentrations in the caudate nucleus were significantly below control levels. 6 The results suggest that p- and m-tyramine may be stored by an intraneuronal reserpine-sensitive storage mechanism. Alternatively, the tyramines may replace some of the catecholamines from their storage granules and then be released as false transmitters by the nervous impulse. The observed changes in tyramine levels might also the fact that these amines may be metabolically related to another amine which is stored in reserpine-sensitive granules.
1 在大鼠脑尾状核中，皮下注射利血平或脑室内注射6-羟基多巴胺后，测定对酪胺和间酪胺的浓度。利血平处理后，分析下丘脑内的β-苯乙胺。2 尾状核中内源性对酪胺和间酪胺以及下丘脑中β-苯乙胺的水平分别为8.02、2.25和2.52 ng/g。3 注射1或10 mg/kg利血平一天后，酪胺浓度降至对照值的20%以下。单剂量利血平（0.4 mg/kg）显著降低尾状核中两种酪胺的含量。用药后45分钟，间酪胺的作用就开始显现。4 利血平不影响下丘脑β-苯乙胺的含量。5 脑室内注射6-羟基多巴胺（250 μg）十天后，尾状核中对酪胺和间酪胺的浓度显著低于对照水平。6 结果表明，对酪胺和间酪胺可能通过神经元内对利血平敏感的储存机制储存。或者，酪胺可能从其储存颗粒中取代一些儿茶酚胺，然后通过神经冲动作为假递质释放。观察到的酪胺水平变化也可能是因为这些胺类可能在代谢上与另一种储存在对利血平敏感颗粒中的胺有关。
