非甾体抗炎药对富含肥大细胞的大鼠腹膜细胞悬液中三磷酸腺苷含量及组胺释放的影响。
The effect of non-steroidal anti-inflammatory drugs on adenosine triphosphate content and histamine release from rat peritoneal cell suspensions rich in mast cells.
作者信息
Champion G D, Day R O, Ray J E, Wade D N
出版信息
Br J Pharmacol. 1977 Jan;59(1):29-33. doi: 10.1111/j.1476-5381.1977.tb06973.x.
Abstract
1 Non-steroidal anti-inflammatory drugs (NSAID) suppressed compound 48/80-induced histamine release from rat peritoneal cells in vitro in a dose-dependent manner. 2 NSAID suppressed the adenosine triphosphate (ATP) content of rat peritoneal cells in vitro and this correlated strongly with the suppression of compound 48/80-induced histamine release. 3 The correlation demonstrated suggests that the mechanism of action of NSAID in the rat peritoneal cells is via depletion of cellular ATP.
摘要
- 非甾体抗炎药（NSAID）在体外以剂量依赖的方式抑制化合物48/80诱导的大鼠腹膜细胞组胺释放。2. NSAID在体外抑制大鼠腹膜细胞的三磷酸腺苷（ATP）含量，且这与抑制化合物48/80诱导的组胺释放密切相关。3. 所显示的这种相关性表明NSAID在大鼠腹膜细胞中的作用机制是通过消耗细胞内的ATP。
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