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1
Successful primate immunization with peptides conjugated to purified protein derivative or mycobacterial heat shock proteins in the absence of adjuvants.在无佐剂情况下，用与纯化蛋白衍生物或分枝杆菌热休克蛋白偶联的肽成功免疫灵长类动物。
Clin Exp Immunol. 1993 Sep;93(3):382-6. doi: 10.1111/j.1365-2249.1993.tb08189.x.
2
Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming.分枝杆菌热休克蛋白作为载体分子。II：使用70 kDa分枝杆菌热休克蛋白作为结合疫苗的载体可避免使用佐剂和卡介苗初免。
Eur J Immunol. 1992 Jun;22(6):1365-72. doi: 10.1002/eji.1830220606.
3
Use of a tuberculin purified protein derivative--Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants.在卡介苗致敏小鼠中使用结核菌素纯化蛋白衍生物——天冬酰胺-丙氨酸-天冬酰胺-脯氨酸缀合物可克服抗体反应的H-2限制，且无需佐剂。
Proc Natl Acad Sci U S A. 1990 Apr;87(8):2960-4. doi: 10.1073/pnas.87.8.2960.
4
Mycobacterial heat-shock proteins as carrier molecules.分枝杆菌热休克蛋白作为载体分子。
Eur J Immunol. 1991 Oct;21(10):2297-302. doi: 10.1002/eji.1830211002.
5
Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen.热休克蛋白作为载体分子：大肠杆菌GroEL和DnaK蛋白介导的体内辅助效应需要与抗原交联。
Clin Exp Immunol. 1994 Nov;98(2):229-33. doi: 10.1111/j.1365-2249.1994.tb06130.x.
6
Assays for adjuvanticity of new formulations and of carrier proteins for inducing antibody responses to selected immunogens in the squirrel monkey Saimiri sciureus.新制剂及载体蛋白在松鼠猴（Saimiri sciureus）中诱导针对选定免疫原的抗体反应的佐剂活性测定。
Immunol Cell Biol. 1994 Apr;72(2):169-75. doi: 10.1038/icb.1994.25.
7
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.浅表性膀胱癌患者经卡介苗（BCG）膀胱内治疗后针对热休克蛋白和其他分枝杆菌抗原的体液免疫反应
Clin Exp Immunol. 1997 Jul;109(1):157-65. doi: 10.1046/j.1365-2249.1997.4141313.x.
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Specificity of antibodies induced after immunization of mice with the mycobacterial heat shock protein of 65 kD.用65kD分枝杆菌热休克蛋白免疫小鼠后诱导产生的抗体的特异性。
Clin Exp Immunol. 1994 Nov;98(2):224-8. doi: 10.1111/j.1365-2249.1994.tb06129.x.
9
Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys.一种嵌合恶性疟原虫裂殖子表面蛋白疫苗在夜猴中的免疫原性。
Malar J. 2016 Mar 15;15:159. doi: 10.1186/s12936-016-1226-5.
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A recombinant Bacille Calmette-Guérin construct expressing the Plasmodium falciparum circumsporozoite protein enhances dendritic cell activation and primes for circumsporozoite-specific memory cells in BALB/c mice.一种表达疟原虫环子孢子蛋白的重组卡介苗构建体增强树突状细胞的激活，并在 BALB/c 小鼠中诱导针对环子孢子蛋白的记忆细胞。
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A novel DNA vaccine containing multiple TB-specific epitopes casted in a natural structure (ECANS) confers protective immunity against pulmonary mycobacterial challenge.一种新型DNA疫苗，其包含以天然结构（ECANS）构建的多个结核特异性表位，可赋予针对肺部分枝杆菌攻击的保护性免疫。
Vaccine. 2009 Aug 27;27(39):5313-9. doi: 10.1016/j.vaccine.2009.06.093. Epub 2009 Jul 16.
3
Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo.一种靶向胃泌素释放肽的新型DNA疫苗引发的特异性抗体可在体内抑制小鼠黑色素瘤生长。
Clin Vaccine Immunol. 2009 Jul;16(7):1033-9. doi: 10.1128/CVI.00046-09. Epub 2009 May 20.
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Exposure to mycobacteria primes the immune system for evolutionarily diverse heat shock proteins.接触分枝杆菌会使免疫系统对进化上不同的热休克蛋白产生预适应。
Infect Immun. 2005 Nov;73(11):7687-96. doi: 10.1128/IAI.73.11.7687-7696.2005.
5
DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.用与KMP11蛋白融合的克氏锥虫热休克蛋白70进行DNA免疫可引发针对该抗原的细胞毒性和体液免疫反应，并带来保护作用。
Infect Immun. 2001 Oct;69(10):6558-63. doi: 10.1128/IAI.69.10.6558-6563.2001.
6
Plasma membrane expression of heat shock protein 60 in vivo in response to infection.体内热休克蛋白60在感染应答时的质膜表达
Infect Immun. 1999 Aug;67(8):4191-200. doi: 10.1128/IAI.67.8.4191-4200.1999.
7
Role of heat shock proteins in protection from and pathogenesis of infectious diseases.热休克蛋白在传染病防御及发病机制中的作用。
Clin Microbiol Rev. 1999 Jan;12(1):19-39. doi: 10.1128/CMR.12.1.19.
8
Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen.热休克蛋白作为载体分子：大肠杆菌GroEL和DnaK蛋白介导的体内辅助效应需要与抗原交联。
Clin Exp Immunol. 1994 Nov;98(2):229-33. doi: 10.1111/j.1365-2249.1994.tb06130.x.
9
Specificity of antibodies induced after immunization of mice with the mycobacterial heat shock protein of 65 kD.用65kD分枝杆菌热休克蛋白免疫小鼠后诱导产生的抗体的特异性。
Clin Exp Immunol. 1994 Nov;98(2):224-8. doi: 10.1111/j.1365-2249.1994.tb06129.x.
10
Induction of opsonizing antibodies after injection of recombinant Plasmodium falciparum vaccine candidate antigens in preimmune Saimiri sciureus monkeys.在免疫前的松鼠猴中注射重组恶性疟原虫疫苗候选抗原后诱导调理素抗体。
Infect Immun. 1995 Feb;63(2):554-62. doi: 10.1128/iai.63.2.554-562.1995.

本文引用的文献

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Priming to heat shock proteins in infants vaccinated against pertussis.百日咳疫苗接种婴儿对热休克蛋白的致敏作用。
J Immunol. 1993 Mar 1;150(5):2025-32.
2
Cloning of Mycobacterium bovis BCG DNA and expression of antigens in Escherichia coli.牛分枝杆菌卡介苗DNA的克隆及抗原在大肠杆菌中的表达。
Infect Immun. 1985 Dec;50(3):800-6. doi: 10.1128/iai.50.3.800-806.1985.
3
The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.小鼠对恶性疟原虫环子孢子重复表位无载体合成聚合物的抗体反应受I-Ab限制：对疟疾疫苗的潜在影响。
J Immunol. 1986 Nov 1;137(9):2952-5.
4
Rationale for the development of an engineered sporozoite malaria vaccine.工程化子孢子疟疾疫苗研发的理论依据。
Adv Immunol. 1989;45:283-334. doi: 10.1016/s0065-2776(08)60695-1.
5
Synthetic T and B cell recognition sites: implications for vaccine development.合成的T细胞和B细胞识别位点：对疫苗开发的意义。
Adv Immunol. 1989;45:195-282. doi: 10.1016/s0065-2776(08)60694-x.
6
1H-NMR studies of synthetic polypeptide models of Plasmodium falciparum circumsporozoite protein tandemly repeated sequence.恶性疟原虫环子孢子蛋白串联重复序列合成多肽模型的¹H-NMR研究
Biopolymers. 1989 Jan;28(1):225-46. doi: 10.1002/bip.360280124.
7
Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.一种与细菌和植物伴侣蛋白以及65千道尔顿分枝杆菌抗原同源的人类线粒体蛋白的一级结构。
Mol Cell Biol. 1989 May;9(5):2279-83. doi: 10.1128/mcb.9.5.2279-2283.1989.
8
Biochemical and antigenic characterization of the Mycobacterium tuberculosis 71kD antigen, a member of the 70kD heat-shock protein family.
Mol Microbiol. 1989 Feb;3(2):125-30. doi: 10.1111/j.1365-2958.1989.tb01801.x.
9
Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes.麻风分枝杆菌和牛分枝杆菌的70千道尔顿抗原与结核分枝杆菌71千道尔顿抗原以及真核生物保守热休克蛋白70的同源性。
Infect Immun. 1989 Jan;57(1):204-12. doi: 10.1128/iai.57.1.204-212.1989.
10
Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG.利用在大肠杆菌K-12中表达的重组抗原来绘制卡介苗免疫显性65千道尔顿蛋白上的B细胞和T细胞表位。
Infect Immun. 1988 Jun;56(6):1633-40. doi: 10.1128/iai.56.6.1633-1640.1988.

在无佐剂情况下，用与纯化蛋白衍生物或分枝杆菌热休克蛋白偶联的肽成功免疫灵长类动物。

Successful primate immunization with peptides conjugated to purified protein derivative or mycobacterial heat shock proteins in the absence of adjuvants.

作者信息

Perraut R, Lussow A R, Gavoille S, Garraud O, Matile H, Tougne C, van Embden J, van der Zee R, Lambert P H, Gysin J

机构信息

World Health Organization-Immunology Research and Training Centre, Department of Pathology, University of Geneva, Switzerland.

出版信息

Clin Exp Immunol. 1993 Sep;93(3):382-6. doi: 10.1111/j.1365-2249.1993.tb08189.x.

DOI:10.1111/j.1365-2249.1993.tb08189.x
PMID:8370164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1554911/
Abstract

We have previously shown in mice that antibodies can be induced to synthetic malaria peptides conjugated to mycobacterial antigens, such as purified protein derivative (PPD) or heat shock proteins (hsp), and given in the absence of adjuvants after a previous priming with bacille Calmette-Guérin (BCG). In the present study we investigated this model of immunization in the non-human primates, Saimiri sciureus monkeys. Monkeys primed with BCG subcutaneously and then immunized subcutaneously with the Plasmodium falciparum sporozoite (NANP)40 synthetic peptide conjugated to PPD or mycobacterial hsp of 65 or 70 kD, in the absence of adjuvants, produced antipeptide and anti-sporozoite IgG antibodies. Interestingly, the carrier effect of the hsp of 70 kD for the induction of anti-(NANP)40 antibodies was also observed in the absence of a previous priming with BCG. These data suggest that such a vaccination strategy may be applied to humans.

摘要

我们之前在小鼠中发现，针对与分枝杆菌抗原（如纯化蛋白衍生物（PPD）或热休克蛋白（hsp））偶联的合成疟疾肽，可以诱导产生抗体，并且在用卡介苗（BCG）进行初次免疫后，无需佐剂即可给予这些肽。在本研究中，我们在非人灵长类动物松鼠猴（Saimiri sciureus monkeys）中研究了这种免疫模型。用BCG皮下免疫的猴子，随后在无佐剂的情况下，皮下注射与PPD或65或70kD的分枝杆菌hsp偶联的恶性疟原虫子孢子（NANP）40合成肽，产生了抗肽和抗子孢子IgG抗体。有趣的是，在没有用BCG进行初次免疫的情况下，也观察到70kD的hsp对诱导抗（NANP）40抗体的载体效应。这些数据表明，这种疫苗接种策略可能适用于人类。