Dion I, Baquey C, Havlik P, Monties J R
Laboratoire de Biophysique, Université de Bordeaux II, France.
Int J Artif Organs. 1993 Jul;16(7):545-50.
In order to evaluate under dynamic circumstances the in vitro platelet adhesion induced by rigid materials such as ceramic coatings deposited on selected substrates, a new model simulating a tube has been designed. In vitro platelet adhesion was assessed with this new model: the material was titanium nitride (TiN) deposited on Ti6A14V (TA6V) titanium alloy by a physical vapor deposition (PVD) process. The results were compared to those obtained with complete titanium carbide (TiC) graphite tubes coated with TiN by a chemical vapor deposition (CVD) process. The difference observed (less than 25%) in favour of the new system, could be due to the better surface state of the construction materials of this system. In fact it is a systemic error. However TiN confirms its good performance as a blood-contacting biomaterial.
为了在动态环境下评估由诸如沉积在选定基材上的陶瓷涂层等刚性材料诱导的体外血小板粘附情况，设计了一种模拟血管的新模型。使用该新模型评估体外血小板粘附情况：材料是通过物理气相沉积（PVD）工艺沉积在Ti6A14V（TA6V）钛合金上的氮化钛（TiN）。将结果与通过化学气相沉积（CVD）工艺涂覆有TiN的完整碳化钛（TiC）石墨管所获得的结果进行比较。观察到有利于新系统的差异（小于25%），这可能是由于该系统构建材料的表面状态更好。实际上这是一个系统误差。然而，TiN证实了其作为血液接触生物材料的良好性能。
