Dion I, Baquey C, Candelon B, Monties J R
Laboratoire de Biophysique, Université de Bordeaux II, France.
Int J Artif Organs. 1992 Oct;15(10):617-21.
The left ventricular assist device is based on the principle of the Maillard-Wenkel rotative pump. The materials which make up the pump must present particular mechanical, tribological, thermal and chemical properties. Titanium nitride (TiN) because of its surface properties and graphite because of its bulk characteristics have been chosen. The present study evaluated the in vitro hemocompatibility of TiN coating deposited by the chemical vapor deposition process. Protein adsorption, platelet retention and hemolysis tests have been carried out. In spite of some disparities, the TiN behavior towards albumin and fibrinogen is interesting, compared with the one of a reference medical grade elastomer. The platelet retention test gives similar results as those achieved with the same elastomer. The hemolysis percentage is near to zero. TiN shows interesting characteristics, as far as mechanical and tribological problems are concerned, and presents very encouraging blood tolerability properties.
左心室辅助装置基于迈拉德 - 温克尔旋转泵的原理。构成该泵的材料必须具备特殊的机械、摩擦学、热学和化学性能。由于其表面特性，选择了氮化钛（TiN），又因其实体特性选择了石墨。本研究评估了通过化学气相沉积工艺沉积的TiN涂层的体外血液相容性。进行了蛋白质吸附、血小板黏附及溶血试验。尽管存在一些差异，但与参考医用级弹性体相比，TiN对白蛋白和纤维蛋白原的表现令人关注。血小板黏附试验得到了与相同弹性体相似的结果。溶血百分比接近零。就机械和摩擦学问题而言，TiN表现出有趣的特性，并呈现出非常令人鼓舞的血液耐受性。
