Dicou E, Hurez D, Nerrière V
INSERM U298, Angers, France.
J Neuroimmunol. 1993 Sep;47(2):159-67. doi: 10.1016/0165-5728(93)90026-u.
High titers of natural autoantibodies against the nerve growth factor (NGF) were detected in the sera of patients with systemic lupus erythematosus, autoimmune thyroiditis and rheumatoid arthritis. Autoantibodies to NGF from these pathological cases displayed higher avidity for NGF and a higher polyreactivity with certain cytoskeletal proteins and with DNA as compared to those from control human subjects. The biological activity, immunoglobulin composition and physiological relevance of these autoantibodies are discussed.
在系统性红斑狼疮、自身免疫性甲状腺炎和类风湿关节炎患者的血清中检测到高滴度的抗神经生长因子（NGF）天然自身抗体。与健康对照者相比，这些病理病例中针对NGF的自身抗体对NGF表现出更高的亲和力，并且与某些细胞骨架蛋白和DNA具有更高的多反应性。本文讨论了这些自身抗体的生物学活性、免疫球蛋白组成和生理相关性。
