Hughes R A
Rheumatology Department, Westminster Hospital, London, UK.
J Rheumatol. 1993 Jul;20(7):1241-2.
We describe the case of a 21-year-old woman who developed biopsy proven seronegative oligoarthritis in association with isotretinoin treatment for acne vulgaris. Elevated levels of antinuclear antibody accompanied joint disease and resolution occurred over a 6-month period. Isotretinoin, an orally active derivative of vitamin A, has been associated with reported arthritis, arthralgia, myalgia, vasculitis and skeletal and soft tissue calcification. We review the literature and discuss the possible association between isotretinoin and immune dysfunction. The etiology of arthritis associated with vitamin A analog treatment remains obscure.
我们描述了一名21岁女性的病例，该患者在接受异维A酸治疗寻常痤疮时出现了经活检证实的血清阴性寡关节炎。抗核抗体水平升高伴随关节疾病，且在6个月内病情得到缓解。异维A酸是维生素A的口服活性衍生物，已有报道称其与关节炎、关节痛、肌痛、血管炎以及骨骼和软组织钙化有关。我们回顾了文献并讨论了异维A酸与免疫功能障碍之间可能存在的关联。与维生素A类似物治疗相关的关节炎病因仍不明确。
