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Hairy cell leukemia: an interphase cytogenetic study.

作者信息

Lewis J P, Tanke H J, Raap A K, Kibbelaar R E, Kluin P M, Kluin-Nelemans H C

机构信息

Department of Cell Biology, University Medical Center, Leiden, The Netherlands.

出版信息

Leukemia. 1993 Sep;7(9):1334-8.

PMID:8371584
Abstract

Malignant cells from 24 cases of hairy cell leukemia were studied by in situ hybridization for evidence of selective aneuploidy using alphoid and satellite probes specific for 16 human chromosomes. Based on these data, hairy cell leukemia appears to be diploid for the chromosomes studied and is a malignancy which displays the phenomenon of pairing of the centromere and p arm of chromosome 15 during interphase.

摘要

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Somatic pairing of centromeres and short arms of chromosome 15 in the hematopoietic and lymphoid system.造血和淋巴系统中15号染色体着丝粒与短臂的体细胞配对。
Hum Genet. 1993 Dec;92(6):577-82. doi: 10.1007/BF00420942.