Department of Biology, Sonoma State University, Rohnert Park, CA, USA.
Department of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Results Probl Cell Differ. 2022;70:191-220. doi: 10.1007/978-3-031-06573-6_6.
Chromosome organization is highly dynamic and plays an essential role during cell function. It was recently found that pairs of the homologous chromosomes are continuously separated at mitosis and display a haploid (1n) chromosome set, or "antipairing," organization in human cells. Here, we provide an introduction to the current knowledge of homologous antipairing in humans and its implications in human disease.
染色体组织具有高度动态性，在细胞功能中起着至关重要的作用。最近发现，在有丝分裂过程中，同源染色体对不断分离，并在人类细胞中表现出单倍体（1n）染色体组或“配对”组织。在这里，我们将介绍人类同源配对的最新知识及其在人类疾病中的意义。
