胃内和静脉注射乙醇对大鼠食物摄入量的影响。

Effect of intragastric and intravenous ethanol on food intake in rats.

作者信息

Giner M, Meguid M M

机构信息

Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.

出版信息

Physiol Behav. 1993 Aug;54(2):399-401. doi: 10.1016/0031-9384(93)90129-4.

DOI:10.1016/0031-9384(93)90129-4

PMID:8372137

Abstract

The effects of a continuous intragastric (via a gastrostomy) and intravenous (via an indwelling jugular catheter) infusion of 3% ethanol at 3 ml/h on food intake was examined in rats randomly assigned to a two period crossover study. The 3% ethanol solution provided 19 kcal/day, which was equivalent to about 50% of the daily caloric intake of the rats. Ethanol significantly decreased food intake irrespective of the route administered. But, reduction in food intake did not result in a calorie-to-calorie compensation. Instead, providing 50% of calories as 3% ethanol via the intragastric route led to a 16% reduction in food intake, while only a 9% reduction in food intake occurred when the 3% ethanol solution was given intravenously.

摘要

在一项随机分配的两阶段交叉研究中，对大鼠进行了如下实验：通过胃造口术持续胃内输注（以3ml/h的速度）和通过颈静脉留置导管静脉输注3%乙醇，研究其对食物摄入量的影响。3%的乙醇溶液每天提供19千卡热量，约占大鼠每日热量摄入量的50%。无论给药途径如何，乙醇均显著降低食物摄入量。但是，食物摄入量的减少并未导致热量与热量之间的补偿。相反，通过胃内途径提供50%的热量作为3%乙醇，导致食物摄入量减少16%，而静脉注射3%乙醇溶液时，食物摄入量仅减少9%。