蓖麻毒素可诱导人外周血单个核细胞产生肿瘤坏死因子-α和白细胞介素-1β。
Ricin induces the production of tumour necrosis factor-alpha and interleukin-1 beta by human peripheral-blood mononuclear cells.
作者信息
Licastro F, Morini M C, Bolognesi A, Stirpe F
机构信息
Dipartimento di Patologia sperimentale dell'Università di Bologna, Italy.
出版信息
Biochem J. 1993 Sep 1;294 ( Pt 2)(Pt 2):517-20. doi: 10.1042/bj2940517.
Abstract
Ricin induced the release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta by human peripheral-blood mononuclear cells in a dose- and time-dependent manner. The inhibition induced by ricin upon the phytohaemagglutinin (PHA)-driven lymphocyte proliferation was greater in cultures of mononuclear cells than that observed in monocyte-free cultures of lymphocytes, and was decreased after addition of an anti-TNF-alpha antibody to PHA-activated cultures. Low levels of TNF-alpha were detected in plasma from rats poisoned with ricin. These results suggest that ricin induced the release of macrophage-derived cytokines which may have a role in the pathogenesis of ricin toxic effects.
摘要
蓖麻毒素以剂量和时间依赖性方式诱导人外周血单个核细胞释放肿瘤坏死因子-α（TNF-α）和白细胞介素-1β。蓖麻毒素对植物血凝素（PHA）驱动的淋巴细胞增殖的抑制作用在单个核细胞培养物中比在无单核细胞的淋巴细胞培养物中更明显，并且在向PHA激活的培养物中添加抗TNF-α抗体后这种抑制作用减弱。在蓖麻毒素中毒的大鼠血浆中检测到低水平的TNF-α。这些结果表明，蓖麻毒素诱导巨噬细胞衍生细胞因子的释放，这些细胞因子可能在蓖麻毒素毒性作用的发病机制中起作用。
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