两种不同时长的口服冷冻疗法预防5-氟尿嘧啶相关性口腔炎的随机临床试验。
A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis.
作者信息
Rocke L K, Loprinzi C L, Lee J K, Kunselman S J, Iverson R K, Finck G, Lifsey D, Glaw K C, Stevens B A, Hatfield A K
机构信息
Illinois Oncology Research Association CCOP, Peoria.
出版信息
Cancer. 1993 Oct 1;72(7):2234-8. doi: 10.1002/1097-0142(19931001)72:7<2234::aid-cncr2820720728>3.0.co;2-n.
BACKGROUND
The authors previously reported that 30 minutes of oral cryotherapy inhibits 5-fluorouracil (5-FU)-induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection.
METHODS
This trial involved patients who were receiving their first course of a 5-FU plus leucovorin chemotherapy regimen, for which stomatitis is a major dose-limiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5-FU therapy.
RESULTS
A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis.
CONCLUSION
The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5-FU-based chemotherapy.
背景
作者之前报道，30分钟的口腔冷冻疗法可抑制5-氟尿嘧啶（5-FU）诱导的口腔炎。当前试验旨在确定更长时间的冷冻疗法是否能提供额外的保护。
方法
该试验纳入了正在接受首个疗程的5-FU加亚叶酸化疗方案的患者，口腔炎是该方案的主要剂量限制性毒性。这些患者被随机分为两组，一组在接受5-FU治疗的同时接受30分钟的口腔冷冻疗法，另一组接受60分钟的口腔冷冻疗法。
结果
共研究了178例可评估患者。两个冷冻疗法组的黏膜炎程度相似。
结论
作者继续推荐，对于接受基于5-FU的大剂量强化化疗疗程的患者，采用30分钟的口腔冷冻疗法。
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