Kutteh W H, Lyda E C, Abraham S M, Wacholtz M C
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
Fertil Steril. 1993 Sep;60(3):449-55. doi: 10.1016/s0015-0282(16)56159-7.
To analyze the pregnancy history in relation to the presence or absence of anticardiolipin antibodies in women who had been diagnosed with systemic lupus erythematosus (SLE).
One-hundred twenty-five women of reproductive age who were diagnosed with SLE and attended the Lupus Clinic at Parkland Memorial Hospital or Southwestern Medical Center were selected for this study. A retrospective review of patient histories, including anticardiolipin antibody test results and pregnancy histories, was conducted. Women who had therapeutic pregnancy terminations were excluded from this study. A chi 2 analysis was used to evaluate the significance of the data.
In women with SLE of childbearing age with anticardiolipin antibodies, a 39% pregnancy loss rate occurred, compared with an 11% loss rate in anticardiolipin antibody-negative women. In women with at least two pregnancies who had anticardiolipin antibodies, 27% experienced two or more losses, whereas only 3% of antibody-negative women had recurrent pregnancy loss.
We conclude that women with SLE and the presence of anticardiolipin antibodies are at increased risk for pregnancy loss.
分析已确诊系统性红斑狼疮（SLE）的女性的妊娠史与抗心磷脂抗体存在与否的关系。
选取125名诊断为SLE且在帕克兰纪念医院或西南医学中心狼疮门诊就诊的育龄女性进行本研究。对患者病史进行回顾性分析，包括抗心磷脂抗体检测结果和妊娠史。本研究排除了接受治疗性终止妊娠的女性。采用卡方分析评估数据的显著性。
在有抗心磷脂抗体的育龄SLE女性中，妊娠丢失率为39%，而抗心磷脂抗体阴性的女性妊娠丢失率为11%。在至少有两次妊娠且有抗心磷脂抗体的女性中，27%经历了两次或更多次妊娠丢失，而抗体阴性的女性中只有3%有复发性妊娠丢失。
我们得出结论，患有SLE且存在抗心磷脂抗体的女性妊娠丢失风险增加。
